WebDec 1, 2024 · Phenytoin clearance is decreased slightly in elderly patients and lower or less frequent dosing may be required [see Clinical Pharmacology (12.3)]. Dosing during Pregnancy Decreased serum … WebNational Center for Biotechnology Information
Phenytoin: Uses, Dosage, Side Effects, Warnings - Drugs.com
WebPhenytoin clearance is decreased slightly in elderly patients and lower or less frequent dosing may be required [see Clinical Pharmacology (12.3)]. dosing during pregnancy Decreased serum concentrations of phenytoin may occur during pregnancy because of altered phenytoin pharmacokinetics. WebThe clearance of phenytoin is non-linear. 10 At lower serum concentrations (less than 10 mg/L), elimination is characterized by first order kinetics. 3 As plasma concentrations … churchtrac free download
Phenytoin: Uses, Interactions, Mechanism of Action - DrugBank
WebPhenytoin clearance tends to decrease with increasing age (20% less in patients over 70 years of age relative to that in patients 20 to 30 years of age). Since phenytoin clearance is decreased slightly in elderly patients, lower or less frequent dosing may be required [see Dosage and Administration (2.7) ] . WebSep 15, 2016 · plasma (e.g. micafungin, phenytoin); interpretation of total plasma level difficult Altered safety: ... Delayed maturation of CYP enzymes contributes to variability in drug clearance . WebPhenytoin: Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. Theophylline decreases phenytoin absorption. Serum theophylline and phenytoin concentrations decrease about 40%. Propafenone: Decreases theophylline clearance and pharmacologic interaction. 40% increase. churchtrac how to do payroll taxes