WebJan 22, 2024 · Myf6 mainly regulates the terminal differentiation of myoblasts and is highly expressed in mature muscle fibers ( Bentzinger et al., 2012 ). As a result, these myoblasts undergo differentiation to either repair damaged muscle fibers or fuse into multi-nuclear myotubes to form new myofibers ( Mashinchian et al., 2024 ). WebJun 23, 2024 · Epigenetic Regulation of Myogenic Cell Differentiation in Hypoxia Recently, it was discovered that the histone demethylase KDM6A (lysine demethylase 6A) prevents cell differentiation by demethylation of H3K27 (histone H3 on lysine 27). Hypoxia can induce H3K27 methylation, which represses the transcription of late myogenic genes such as …
Skeletal muscle atrophy, regeneration, and dysfunction
WebMyogenic factor 6. Short names. Myf-6. Alternative names. Class C basic helix-loop-helix protein 4 (bHLHc4) Muscle-specific regulatory factor 4; Gene names. Name. MYF6. … WebMar 15, 2024 · Myogenesis initializes the proliferation and differentiation of myoblasts into muscle cells, and consequently the fusion of muscle cells into myotubes, which in turn leads to the maturation of muscle fibers [ 7 ]. miRNAs are noncoding single-stranded RNAs that can block translation or elicit degradation of target genes [ 8 ]. federal credit union rapid city south dakota
UniProt
WebDec 13, 2013 · Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development.... WebJun 15, 2005 · Epistatic relations among the myogenic bHLH factors. Shh and Wnt signaling from the notochord the dorsal neural tube, respectively, have been viewed to govern the expression of Myf5 in the epaxial dermamyotome of the somite (green). Pax3 and Myf5 independently regulate Myod expression. Myogenic factor 6 (also known as Mrf4 or herculin) is a protein that in humans is encoded by the MYF6 gene. This gene is also known in the biomedical literature as MRF4 and herculin. MYF6 is a myogenic regulatory factor (MRF) involved in the process known as myogenesis. See more MYF6/Mrf4 is a member of the myogenic factor (MRF) family of transcription factors that regulate skeletal muscle myogenesis and muscle regeneration. Myogenic factors are basic helix-loop-helix (bHLH) transcription factors. … See more Mutations in the MYF6 gene are associated with autosomal dominant centronuclear myopathy (ADCNM) and Becker's muscular dystrophy. See more • Braun, T.; Arnold, H. H. (1991). "The four human muscle regulatory helix-loop-helix proteins Myf3-Myf6 exhibit similar hetero-dimerization and DNA binding properties". Nucleic Acids … See more federal credit union new hartford ny