Granulophysin
WebThese characteristics are similar to an individual with Hermansky-Pudlak syndrome and are consistent with a platelet dense granule deficiency. In contrast, immunofluorescence studies using an antibody against the dense granule membrane protein granulophysin suggested that both sisters had numbers of granules within the normal range. WebTarget Information. CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation …
Granulophysin
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WebThe H5C6 monoclonal antibody specifically binds to CD63. CD63 is a 53 kDa, type III lysosomal glycoprotein, expressed on activated platelets, monocytes and macrophages. This molecule is also referred to in the literature as LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, LAMP-3 and is a member of the tetraspan transmembrane 4 … WebCD63 molecule. Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and ...
WebJun 1, 1994 · Granulophysin expression on the surface membrane of the neutrophil is increased following stimulation of the cells, demonstrated by flow cytometry and fine structural immunocytochemistry. A similar pattern is shown for an anti-CD63 antibody. Incubation of activated neutrophils with D545, a monoclonal antibody to granulophysin, … WebJun 15, 2000 · It can only be identified by GPIb-specific expression on its plasma membrane (pm). Granulophysin labels the membrane of vacuolar structures, which can be …
WebSep 1, 1992 · Recently the platelet protein granulophysin, specific to the membrane of the DG, has been described and defined through the use of monoclonal antibodies … WebPE-Cy7 is a tandem fluorochrome composed of R-phycoerythrin (PE), which is excited by 488-nm light and serves as an energy donor, coupled to the cyanine dye Cy7, which acts as an energy acceptor and fluoresces maximally at 780 nm. PE-Cy7 tandem fluorochrome emission is collected in a detector for fluorescence wavelengths of 750 nm and higher.
Webnoun. gran· u· lo· poi· e· sis - (ˌ)lō-ˌpȯi-ˈē-səs. plural granulopoieses -ˌsēz. : the formation of blood granulocytes typically in the bone marrow. called also granulocytopoiesis. …
WebDescription: Homo sapiens CD63 molecule (CD63), transcript variant 3, mRNA. (from RefSeq NM_001257389) RefSeq Summary (NM_001257389): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the … how many grams in 3 cups baby spinachWeb2024 CiteAb Awards - View the winners now! ... Search how many grams in 4.4 ozWebApr 1, 1994 · In lysates prepared from prostasomes, a broad band of 32 to 37 kd was detected by Western blotting. Conclusion This report defines granulophysin as a constituent membrane molecule of prostasomes that may serve as a useful marker in elucidation of prostasome function. Key Words Human seminal plasma prostasomes … how many grams in 3 eggsWebGranulophysin Lysosomal-associated membrane protein 3 LAMP-3 Melanoma-associated antigen ME491 OMA81H Ocular melanoma-associated antigen Tetraspanin-30 Tspan-30 CD antigen CD63. From Uniport. CD63 Gene family protein . CD molecules . Approved symbol Common name; BTN3A1: BTN3A1 protein, recombinant: LAMP1: hovering cannon tower of fantasyWebGranulophysin, a protein described in platelet dense granule membranes, has been shown to be similar or identical to CD63, a lysosomal membrane protein. We have previously shown granulophysin to ... hovering cars fivemWebNaked mole-rats are long-lived animals that show unusual resistance to hypoxia, cancer and ageing. Protein deimination is an irreversible post-translational modification caused by the peptidylarginine deiminase (PAD) family of enzymes, which convert arginine into citrulline in target proteins. Protein deimination can cause structural and functional protein changes, … hovering carriageWebJul 1, 1992 · We recently reported the characterization of a platelet granule membrane protein of molecular weight (mol wt) 40,000 called granulophysin (Gerrard et al: Blood … how many grams in 4 cups of water