WebMar 31, 2011 · These studies suggest that Cyr61 and CTGF are 2 critical TAZ transcriptional targets mediating TAZ-induced drug resistance in breast cancer cells. Together, our studies provided the first biological evidence that overexpression of the TAZ oncogene can cause drug resistance of breast cancer cells through direct activation of 2 secreted and ... WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …
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WebJul 8, 2013 · Accordingly, we investigated the function of connective tissue growth factor (CTGF), a protein known to be important in stromal formation. CTGF is a pleiotropic and cysteine-rich matricellular protein that is abundant in many solid malignancies including pancreas, breast, esophageal, glioblastoma, and hepatocellular carcinoma ( 18 – 23 ). WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth …
WebJul 18, 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … WebJun 6, 2012 · Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are …
WebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma. WebSep 15, 2024 · Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth …
WebAug 8, 2024 · Lai, D., Ho, K. C., Hao, Y. & Yang, X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res ...
WebCTGF expression has been tied in with tumor growth, invasion, and metastasis. It shows aberrant expression in many forms of cancer, such as prostate, breast, and esophageal … great stuff foam reviewWebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. florham nj countyWebJun 16, 2024 · FibroGen's pamrevlumab is a first-in-class antibody that inhibits the activity of connective tissue growth factor (CTGF), which, in cancer, is characterized by promotion of tumor growth. florham park auto bodyWebFeb 28, 2024 · Results . AuNPs were able to decrease the density of colorectal cancer associated fibroblasts (CAFs), to reduce the production of tumor stromal collagen I, and to diminish the expression of profibrotic signals, including CTGF, TGF-β1 as well as VEGF in vivo and vitro via Akt signaling pathway. great stuff foam sealant gaps and cracks sdsWebJul 27, 2024 · In this AM dataset, we annotated a new subcluster of fibroblasts, CTGF + CAFs, which might be a key factor in AM tumor occurrence and metastasis. CTGF + CAFs act on malignant cells … florham park borough tax collectorWebApr 20, 2024 · a The efficacies of the first-line anti-cancer drugs (Cisplatin and 5-FU) were assessed on GC cells after knocking down AMOTL1, YAP1, CTGF, and control, respectively. b The IC 50 of VP was ... florham park board of education employmentWebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … great stuff foam refill home depot