Cisplatin hplc

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WebNov 1, 2008 · Purpose: The purpose of this study was to develop and validate HPLC-UV method for the determination of the cisplatin, based … WebFeb 28, 2024 · Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels. Xiaoxu Zhao 1 Department of General Surgery, ... HPLC analysis detected high concentrations of cisplatin in tumors after combined therapy, both of which indicated that the delivery efficacy of cisplatin was …

The UV visible spectrum of cisplatin solution. Download …

WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent forms several DNA adducts, a highly sensitive and specific quantitative assay is needed to correlate the molecular dose of individual adducts with the effects of treatment. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … eastern police district headquarters

Low-level (PPB) determination of cisplatin in cleaning

WebMar 1, 2024 · Cisplatin is a platinum containing compound used for the treatment of different types of cancers. Quantitative determination of cisplatin has been carried out using atomic absorption spectroscopy, high pressure liquid chromatography with phosphorescence, ultra-violet detection, or with inductively coupled plasma mass … Webcisplatin-plus lipoic acid (50 and 100 mg/kg)-treated rats, renal GSH-peroxidase activity signiﬁcantly increased as compared to cisplatin alone (P ,0.01 and P 0.01) (ﬁg. 3). The renal GSH-peroxidase activity in lipoic acid (100 mg/ kg) alone treated group was 247.02”15.52 mmoles NADPH oxidized/min./mg protein which was close to control value. WebKey Words:Oxaliplatin, RP-HPLC, UV detection, recovery, precise, 240nm INTRODUCTION Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. oxaliplatin is the platinum-containing complex similar to cisplatin. This agent was recently approved for use as a second line therapy in metastatic colorectal cancer. eastern poison ivy

High performance liquid chromatography: Tandem mass spectrometric ...

Development and validation of a LC-MS/MS assay for ... - PubMed

WebA potent platinum-based antineoplastic drug. Its mode of action involves formation of inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I. Cisplatin synergizes with a variety of anticancer agents. WebJan 7, 2024 · Cancer is known to be one of the major causes of death nowadays. Among others, chemotherapy with cisplatin is a commonly used treatment. Although widely employed, cisplatin is known to cause severe side effects, such as nerve and kidney damage, nausea, vomiting, and bone marrow suppression. Most importantly, a number … eastern police investigation centre phoneWebMar 1, 2024 · Cisplatin (Platinol ®) is a chemotherapeutic agent, first approved by the U.S. Food and Drug Administration (FDA) in 1978 for the treatment of ovarian cancer and finds its use nowadays for the treatment of various types of cancer including cervical cancer, testicular cancer and germ cell tumors [1]. eastern police academy

"WebCisplatin analysis by HPLC especially in biologic samples is challenging due to formation of different species and its high reactivity. Derivation by specific agents can serve a simpler … " - Cisplatin hplc

Cisplatin hplc

HPLC method for the determination of carboplatin and paclitaxel …

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … WebCisplatin is an anti-tumor agent widely employed in cancer chemotherapy. A specific and selective method for the quantitative determination of cisplatin in human plasma and its …

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WebSep 18, 2024 · National Center for Biotechnology Information WebDescription. Analysis Note. Antineoplastic agents separated with excellent resolution. Featured Industry. Pharmaceutical (small molecule) Legal Information. LiChrosolv is a …

WebFeb 26, 2015 · Cisplatin and apigenin were purchased from Sigma-Aldrich (St. Louis, MO, USA). All other reagents were of analytical grade or HPLC grade, and were obtained from DIMA Technology, Inc. (Richmond Hill, GA, USA). Analytical procedures. Cisplatin was separated by HPLC using a Symmetry C18 column (50×2.1 mm; Waters Corporation, … WebC is-diamminedichloroplatinum(II) (cisplatin) is the most celebrated metal-based chemotherapeutic in the history of modern medicine.The discovery of its anticancer effects was not only opportune [1,2,3], especially during a period when cancer prevention was desperately needed, but also because medical oncology did not yet exist as a clinical …

WebCisplatin Synonyms: cis-Diammineplatinum (II) dichloride, cis-Dichlorodiammine platinum (II), cis-Platinum (II) diammine dichloride, Cisplatin Linear Formula: Pt (NH3)2Cl2 CAS Number: 15663-27-1 Molecular Weight: 300.05 EC Number: 239-733-8 Product Comparison Guide Use the product attributes below to configure the comparison table. WebCisplatin is an antineoplastic drug used for the treatment of cancer patients with a variety of different malignancies. Application Cisplatin may be used as an analytical reference standard for the determination of the analyte in plasma, cancer cell, and tumor samples by high-performance liquid chromatographic assay.

WebHPLC is a useful technique for monitoring 2 and 3, but only if the components of the mobile phase used in the reverse phase HPLC technique are unreactive toward these aqua complexes under the conditions of the experiment. 15N Nuclear magnetic resonance (NMR) with samples highly enriched (>98%) in 15N has been used to check the reactivity of 2 …

WebNov 1, 2005 · Although a number of methods have been described for the determination of cisplatin in human fluids by high-performance liquid chromatography (HPLC), there are … cuisinart enameled aluminum cookware reviewsWebneeded. As cisplatin is a metal-based molecule, historical analyses include phosphorescence, high-performance liquid chromatography with ultraviolet visible … cuisinart em 1 steam wandWebMethods: A microemulsion method was employed to generate lipid coated cisplatin/oleanolic acid calcium carbonate nanoparticles (CDDP/OA-LCC NPs), and the loading concentration of CDDP and OA was measured by atomic absorption spectroscopy and HPLC respectively.Transmission electron microscopy (TEM) was used to examine … eastern police investigation centre postcodeWebThe platinum content (4.91%) of Polycisplatin was determined by modified HPLC–UV method detailed in the literature. 19 Briefly, a known amount of Polycisplatin was dissolved in 0.5 M HCl solution and stirred so as to cleave the AA-Pt bond and release the cisplatin. The cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and ... eastern poison ivy picturesWebNational Center for Biotechnology Information eastern point of indiaWebAug 19, 2005 · Cisplatin is a widely used anti-tumor agent for the treatment of testicular and ovarian cancers. Carboplatin is used extensively for small cell, non small cell lung cancer … cuisinart espresso coffee makersWebGemcitabine (Gem) and cisplatin (Cis) are currently being used for lung cancer treatment, but they are highly toxic in high dosages. This research aimed to develop a niosome formulation... eastern polish