Cisplatin and apoptosis
WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Synonym (s): Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum Linear Formula: Pt (NH3)2Cl2 CAS Number: 15663-27-1 MDL number: MFCD00011623 NACRES: NA.77 WebMay 1, 2008 · Interestingly, cisplatin can also induce necrosis and apoptosis in cultured endothelial cells, although evidence is yet to be demonstrated for endothelial cell apoptosis during cisplatin nephrotoxicity in vivo. 44 APOPTOTIC PATHWAYS IN CISPLATIN NEPHROTOXICITY
Cisplatin and apoptosis
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WebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy. WebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have cisplatin as a drip into your bloodstream (intravenously). Into your bloodstream You might have treatment through a long plastic tube that goes into a large vein in your chest.
WebIn summary, a growing body of evidence suggests that cisplatin-induced cell death does not always come from "classic"apoptosis. Depending on both cisplatin dose and cellular … WebMar 15, 2024 · Cell viability and proliferation were detected by counting kit 8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays respectively. Apoptosis and cell cycle were analyzed by flow cytometry. The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis.
WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … WebOct 5, 2014 · Because cisplatin is a DNA-damaging agent and an inducer of apoptosis, it is reasonable to expect changes in HSPs in the development of cellular resistance …
WebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis within …
WebJan 30, 2024 · While apoptosis activation pathways were not observed in DRG sensory neurons of cisplatin-treated mice, these neurons did express several senescence hallmarks, including senescence-associated β-galactosidase, phospho-H2AX, and nuclear factor kappa B (Nfkb)-p65 proteins. in china there is an oldWebJan 29, 2024 · Apoptosis and necroptosis were previously reported to be the major pathological processes of acute kidney injury, however, preclinical works using specific inhibitor of neither apoptosis or... in china today newsWebJan 5, 2016 · In conclusion, NF-κB transcriptional inhibition in cisplatin-induced AKI ameliorates kidney function and ATN without a significant effect on apoptosis and is associated with a decrease pro-inflammatory mediators and CARD11. Keywords: Acute kidney injury; Apoptosis; Cisplatin; NF-κB; Necrosis. Copyright © 2015. Published by … early morning taxi service near meWebSep 5, 2011 · Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma. Clin Cancer Res 15: 1645–1654. in china this is the year of the whatWebMar 9, 2024 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. in china we open a gift later课件WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... early morning work ideasWebJan 6, 2024 · Cisplatin is a mainstay of systemic therapy for a variety of cancers, such as lung cancer, head and neck cancer, and ovarian cancer. However, resistance to cisplatin represents one of the most significant barriers for patient outcome improvement. in china traditionally the elderly were