Cisdiamminedichloroplatinum
WebJan 1, 1987 · Abstract. Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin-sensitive A2780 line to increasing concentrations of cisplatin. 2780CP8 (CP8 refers to this cell line's growth in medium containing 8 µm cisplatin) has several clonal cytogenetic abnormalities but lacks … Web1-β-D-Arabinofuranosylcytosine (ara-C) and hydroxyurea (HU) were investigated as possible inhibitors for the repair of cis-diamminedichloroplatinum(II) (DDP)-induced DNA damage. HU and ara-C were chosen for their known ability to …
Cisdiamminedichloroplatinum
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Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... WebWe demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the …
WebApr 19, 2024 · A platinum-based chemotherapeutic agent, Cisplatin (CDDP), has been widely used to treat many human cancer including cervical cancer, metastatic cancers and most of other solid tumors [1]. The cisplatin anticancer efficacy is owing to its interaction with chromosomal DNA. Weba platinum coordination compound whose main mode of action resembles that of alkylating agents with production of cross links between the two strands of DNA in the double helix …
WebJan 29, 1985 · Salmon sperm DNA, treated with the antitumor agent cis-diamminedichloroplatinum(II) (cis-DDP), was enzymatically degraded to … WebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function …
WebMar 1, 1979 · 1. Cisplatin is a co-ordination complex of a central platinum atom, two chlordies and two ammonia molecules in the “ cis ” position. 2. A prime mechanism of …
Web目的应用免疫组化方法观察豚鼠内耳S-100蛋白的表达。方法选用健康,Preyer’s反射正常豚鼠8只,4%多聚甲醛活体灌注后耳蜗冰冻切片,采取SP免疫组化方法进行S-100蛋白染色。结果耳蜗Corti’s器内外毛细胞,Deiter及Hensen细胞呈阳性表达,基底膜下细胞未着色,螺旋缘齿间细胞,螺旋神经节细胞间纤维,螺旋韧带及 ... great harvest bread peoria ilWebThe thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP). flnb-related spectrum disordersWebAbstract Murine leukemia L1210 cells, either sensitive or resistant to the toxic action of the cancer chemotherapeutic agent cis-diamminedichloroplatinum (II), have been studied … great harvest bread order pick upWebCisplatin (cis-diamminedichloroplatinum) is an alkylating agent and a subset of platinum (II) analogs. It acts by producing an immensely reactive moiety that facilitates the cross … great harvest bread pasco waWebShort-term cis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells We examined the short-term accumulation of cisplatin (DDP) in sensitive 2008 human ovarian carcinoma cells and in a 2- to 3-fold DDP-resistant and accumulation-deficient variant. great harvest bread pascoWebJun 1, 1975 · Summary. The effects of cis -diamminedichloroplatinum (NSC 119875) on murine and human hemopoietic precursor cells were studied in culture. When murine … great harvest bread peoria il menuWebFeb 25, 2016 · Platinum, being a 5d metal, has d orbitals that are larger than the 3d orbitals, allowing for a more spread out electron density. That decreases the coulombic repulsion energy, which we will call Πc. The … fln christmas stream