Chromopyrrolic acid
WebJun 29, 2024 · 从链霉菌分离出的咔唑生物碱星孢菌素 (Staurosporine)具有强抗癌作用, 其生物合成的关键步 骤是由 P450 StaP 催化底物色素吡咯酸(chromopyrrolic acid, CPA)氧化脱氢, 形成分子内 C—C 键成咔唑环, 经 氧化脱羧完成. WebAug 5, 2024 · Indolocarbazoles are biosynthesized through the successive modification of chromopyrrolic acid, a dimer of tryptophan. Furthermore, they are closely related to other groups of tryptophan derived natural products, most significantly the indolotryptolines.
Chromopyrrolic acid
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Webchlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 10), A S. albus andA ... WebHere, we have coupled a chemical-biogeographic survey of chromopyrrolic acid synthase (CPAS) gene diversity with targeted eDNA library …
Web≥97% Synonym (s): 3- (3-Indolyl)-2-oxopropanoic acid, 3-Indolylpyruvic acid Empirical Formula (Hill Notation): C11H9NO3 CAS Number: 392-12-1 Molecular Weight: 203.19 Beilstein: 172966 EC Number: 206-874-1 … WebJan 23, 2006 · StaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the ...
WebStaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the presence of RebC directs formation of arcyriaflavin A. 18 O-Labeling studies indicate that the oxygen(s) of the pyrrolinone and maleimide functionalities of ... WebChromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial …
WebSep 25, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product …
Webtion of tryptophan to the imine form of indole-3-pyruvic acid (IPA imine), and StaD then catalyzes the coupling of two molecules of IPA imine to yield chromopyrrolic acid (CPA). Finally, the key skeleton structure referred to as the indolocar-bazole core is constructed through the following two oxidation steps by StaP and StaC (2, 4) (Fig. 1B). chineham energy recovery facilityWebNIOSH. At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that … chineham football clubWebFeb 6, 2013 · Howard-Jones, A.R.; Walsh, C.T. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry 2005, 44, 15652–15663. [Google Scholar] Onaka, H. Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by … grand canyon university graduate tuitionWebMolecules 2024, 25, 256 8 of 16 Gene expression elucidated that 3 is solely required by the tetrameric hemoprotein StaD or RebD for the production of the chromopyrrolic acid 4 in staurosporine or rebeccamycin biosynthesis [45,49], contrary to the previous reports that both 2 and 3 are the precursors for the coupling reaction to yield 4 [38,45]. chineham england united kingdomWebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of … chineham golf societyWebApr 5, 2012 · The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. chineham fireworksWebJan 11, 2005 · The results suggest that indolocarbazole is constructed by oxidative decarboxylation of chromopyrrolic acid generated from two molecules of tryptophan by coupling and that the oxidation state at the C-7 position depends on the additional enzyme(s) encoded by the biosynthetic genes. Expand grand canyon university graduation rings